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Senior Scientist, Medicinal Chemistry

Company: Takeda Pharmaceutical
Location: Brockton
Posted on: May 12, 2022

Job Description:

By clicking the "Apply" button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda's and . I further attest that all information I submit in my employment application is true to the best of my knowledge.Job DescriptionSenior Scientist , Medicinal ChemistryAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a SR Scientist , Medicinal Chemistry in our Cambridge, MA office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.As a SR Scientist working on the Medicinal Chemistry team, you will be empowered to apply innovative synthetic organic and medicinal chemistry principles and techniques toward the discovery of medicines for oncology, neuroscience, GI diseases, and rare diseases.OBJECTIVES: - We are seeking a creative and highly motivated medicinal chemist with several years of industry experience to join us to implement a diverse array of chemistry-based therapeutic modalities toward the development of medicines for oncology, neuroscience, GI, and rare diseases, with a particular focus on targeted protein degradation, RNA modulation, and protein/small molecule conjugation.

  • Candidate should have significant experience in chemistry-based drug discovery, including managing matrixed project teams and programs.
  • Candidate will independently design, develop and execute research assignments (both laboratory and non-laboratory-based) across a variety of projects, acting as senior scientific consultant or as a project team lead.
  • Candidate will be expected to interact and collaborate with cross-functional scientists throughout the Takeda research organization, as well as external partner organizations.ACCOUNTABILITIES: -
    • Develop and oversee the design, synthesis, and characterization of biologically active molecules with suitable drug-like properties; will manage the work of others directly or in a matrixed structure.
    • Champion new chemistry directions and contribute to platform-related activities for chemistry-based therapeutic modalities such as targeted protein degradation, RNA modulation, and protein/small molecule conjugation.
    • Scientifically assess and recommend vendors, and manage the preparation and submission of requests to contract research organizations (CROs) for project-related chemistry.
    • Ensure the appropriate conduct of studies, lead the interpretation of study results, and prepare study reports suitable for internal or regulatory use
    • Act as scientific resource for programs, taking a leading role in the development of project strategy, as well as communication and analysis of complex data to both chemists and non-chemists.
    • Develop and leverage strong collaborations with cross-functional scientists as a key member of a multidisciplinary drug discovery project team.
    • Use scientific expertise in medicinal chemistry, modern chemistry literature, principles of drug design, and breadth of experience working with other disciplines (computational chemistry, biophysical and biochemical assays, and DMPK) to develop solutions and strategies suitable to identify high quality candidates for drug discovery programs.
    • Regularly communicate project data, status and key issues to discovery team and management through presentations in a variety of forums, including high visibility global meetings.
    • Acts as the recognized scientific resource on an aspect of a program.EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:
      • Ph.D. degree with 5+ years of experience, or Master's degree in a scientific discipline, or equivalent with 10+ years of experience or Bachelor's degree in a scientific discipline, or equivalent with 12+ years of experience
      • Broad technical program knowledge.
      • Project management skills and proficiency with scientific data-base, collaboration, and modelling tools
      • Experience preparing experimental section of a patent and/or scientific journal manuscript preparation
      • Significant experience with lab instrumentation such as NMR, LCMS, and ISCO purification systemsTRAVEL REQUIREMENTS:
        • None requiredPHYSICAL DEMANDS:
          • Carrying, handling and reaching for objects up to 25 lbs.
          • Prolonged standing and/or sitting
          • Exposure to hazardous/toxic/dangerous chemicals
          • Manual dexterity required to operate office and lab equipment - -VACCINATION REQUIREMENTS:
            • Effective November 1, 2021, absent an approved religious or medical reason, all US office-based and lab-based Takeda employees who work fully on-site or in a hybrid model (as determined by Takeda) must be fully vaccinated to work at a Takeda site or to engage with Takeda colleagues or anyone else on behalf of Takeda. As of the same date, absent an approved religious or medical reason, US field-based employees, employees must be fully vaccinated in order to continue in their current roles. - US employees who work at a Takeda manufacturing facility, and those who work at a BioLife center or BioLife lab, may be subject to different guidelines. Candidates are encouraged to speak with their recruiter to seek further information on the applicable guidelines for the Business Unit/Function for which they have applied.WHAT TAKEDA CAN OFFER YOU:--- 401(k) with company match and Annual Retirement Contribution Plan--- Tuition reimbursement--- Company match of charitable contributions--- Health & Wellness programs including onsite flu shots and health screenings--- Generous time off for vacation and the option to purchase additional vacation days--- Community Outreach ProgramsEmpowering Our People to ShineDiscover more at takedajobs.comNo Phone Calls or Recruiters Please. #LI-JV2EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.LocationsBoston, MAWorker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time

Keywords: Takeda Pharmaceutical, Brockton , Senior Scientist, Medicinal Chemistry, Other , Brockton, Massachusetts

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